In vitro assessment of the mutagenic and genotoxic potential of a pure stilbene extract

Stilbenes are secondary metabolites of great interest produced by many plant species due to their important bioactive properties. These phytochemicals have become increasing in the wine industry as a natural alternative sulphur dioxide, which has been associated with human health risks. However, there is still little toxicological information on stilbenes and results thus far contradictory. Considering key role genotoxicity risk assessment need offer safe products market, aim this study was assess mutagenic genotoxic potential stilbene extract 99% purity (ST-99 extract). A complete series different vitro tests (Ames test, micronucleus (MN) standard enzyme-modified comet assays) performed before its use preservative wines. The ST-99 induces significant increase binucleated cells micronuclei only presence metabolic fraction S9 at highest concentration assayed. Neither Ames test nor assay revealed extract's potential. Further studies necessary, including vivo assays, ensure consumer safety it can be used.